College of American Pathologists

2012 — April Case of the Month

Posted April 10, 2012

CLINICAL SUMMARY: Central nervous system  

CAP Foundation April Online Case of the Month

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A 55-year-old man presented with a one year history of insidiously progressive neurobehavioral deficits, most recently confusion, mild left hemiparesis, and an abnormal gait. MRI of the brain showed extensive hyperintensity of the frontal white matter, somewhat more prominent on the right, extending to the temporal lobes, diencephalon, midbrain, and pons. A diagnostic biopsy was performed. The patient succumbed within one year.

The master list with the correct answer

  • Alzheimer disease
  • Autoimmune encephalitis
  • Creutzfeldt-Jakob disease
  • Gliomatosis cerebri
  • Multiple sclerosis
  • Pilocytic astrocytoma
  • Viral encephalitis

Access Case Critique to view:

  • Appropriate diagnosis
  • Critique
  • References

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