College of American Pathologists
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  CKD and drug dosing NKDEP recommendations


CAP Today




March 2010
Feature Story

  • Use a single kidney function estimate to guide detection, evaluation, and management of chronic kidney disease and drug dosing.

  • Use eGFR or eCrCl for drug dosing.

  • If using eGFR in very large or very small patients, multiply the reported eGFR by the estimated body surface area to obtain eGFR in units of mL/min.

  • Consider assessing kidney function using alternative methods such as measured CrCl or measured GFR using exogenous filtration markers when prescribing drugs with narrow therapeutic indices, or for individuals in whom eGFR and eCrCl provide different estimates of kidney function, or for individuals in whom any estimates based on creatinine are likely to be inaccurate.

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