College of American Pathologists
CAP Committees & Leadership CAP Calendar of Events Estore CAP Media Center CAP Foundation
 
About CAP    Career Center    Contact Us      
Search: Search
  [Advanced Search]  
 
CAP Home CAP Advocacy CAP Reference Resources and Publications CAP Education Programs CAP Accreditation and Laboratory Improvement CAP Members
CAP Home > CAP Reference Resources and Publications > cap_today/cap_today_index.html > CAP Today Archive 2002 > Genetic model of human urothelial carcinogenesis
Printable Version

  Feature Story

title
 

cap today

Genetic model of
human urothelial carcinogenesis

Back to Cover Story

March 2002
Sidebar

Genetic model of human urothelial carcinogenesis

Outer circle represents chromosomal vectors aligned clockwise from p to q arms, with positions of altered markers exhibiting loss of heterozygosity (LOH). All the markers are positioned on the vectors according to the human genome database (version March 14, 1996). The innermost concentric circles represent major phases of development and progression of urothelial neoplasia from normal urothelium (NU) through low-grade intraurothelial neoplasia (LGIN) and high-grade intraurothelial neoplasia (HGIN) to transitional cell carcinoma (TCC). Solid circles denote statistically significant LOH of the markers defined by the logarithm of odds score analysis. Open circles identify LOH without statistically significant association to a given stage of neoplasia. The positions of open or solid circles on appropriate concentric circles relate the alterations to a given phase of neoplasia. Only markers with LOH are positioned on the chromosomal vectors. Solid bars on outer brackets represent clusters of markers with significant LOH and denote location of putative tumor suppressor genes involved in urothelial neoplasia. The distances of markers on chromosomal vectors and the solid bars depicting minimal deleted regions were adjusted to fit the circle and are not drawn to scale. More precise localization of these regions can be obtained from individual chromosomal vectors.

Reprinted by permission of Wiley-Liss Inc., a subsidiary of John Wiley & Sons Inc. Czerniak B, et al. Genetic modeling of human urinary bladder carcinogenesis. Genes Chromosomes Cancer. 2000;27:392-402.

   
 

 

 

   
 
 © 2014 College of American Pathologists. All rights reserved. | Terms and Conditions | CAP ConnectFollow Us on FacebookFollow Us on LinkedInFollow Us on TwitterFollow Us on YouTubeFollow Us on FlickrSubscribe to a CAP RSS Feed