- The 2001 Bethesda System terminology is used
for cytologic classification (for example, LSIL and HSIL).
- A two-tiered grading for histologic classification
is used for precursor lesions: CIN1 and CIN2,3.
- CIN in endocervical curettings should be graded,
if possible—that is, CIN1 versus CIN2,3.
- CIN1 should be followed without treatment—for
up to two years. o In adolescents, separate CIN2 and CIN3, if possible—management
- A histologic diagnosis of CIN2 in the adolescent
should be initially followed conservatively.
Dr. Darragh, a member of the CAP Cytopathology Committee, is professor of clinical pathology, Departments of Pathology and Ob/Gyn, University of California San Francisco/Mt. Zion Medical Center, San Francisco. Dr. Colgan, a former member of the Cytopathology Committee, is chief, gynecologic pathology, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, and professor, University of Toronto.