College of American Pathologists
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  Table 1: Key points for pathologists:
  ASCCP 2006 consensus guidelines





November 2007
PAP/NGC Programs Review

Teresa M. Darragh, MD
Terence J. Colgan, MD

  • The 2001 Bethesda System terminology is used for cytologic classification (for example, LSIL and HSIL).
  • A two-tiered grading for histologic classification is used for precursor lesions: CIN1 and CIN2,3.
  • CIN in endocervical curettings should be graded, if possible—that is, CIN1 versus CIN2,3.
  • CIN1 should be followed without treatment—for up to two years. o In adolescents, separate CIN2 and CIN3, if possible—management differs.
  • A histologic diagnosis of CIN2 in the adolescent should be initially followed conservatively.

Dr. Darragh, a member of the CAP Cytopathology Committee, is professor of clinical pathology, Departments of Pathology and Ob/Gyn, University of California San Francisco/Mt. Zion Medical Center, San Francisco. Dr. Colgan, a former member of the Cytopathology Committee, is chief, gynecologic pathology, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, and professor, University of Toronto.

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