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 Cancer Protocols

 

Updated December 2, 2014

CAP Announces the Release of New Cancer Biomarker Reporting Templates

In an effort to improve consistency and completeness in reporting of cancer biomarkers, the College of American Pathologists has produced new cancer biomarker templates for reporting results of testing performed on CNS, GIST, and hematopoietic disorder specimens. Additionally, the previously released breast and colorectal biomarker templates have been revised.

The cancer biomarker reporting templates are being produced in response to pathologist feedback about timing of reporting and structural consistency of the ancillary studies data elements found in the CAP Cancer Protocols. The development of these templates is a collaborative effort between CAP, AMP, ASCO and many other participating organizations.

This release includes the following:

  • New CNS Biomarker Template
  • Updated CNS Protocol
  • New GIST Biomarker Template
  • Updated GIST Protocol
  • New Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Biomarker Template
  • New Chronic Myelogenous Leukemia Biomarker Template
  • New Diffuse Large B-Cell Lymphoma Biomarker Template
  • New Myeloproliferative Neoplasms Biomarker Template
  • Updated Breast Biomarker Template
  • Updated Colorectal Biomarker Template

The CAP produces Cancer Protocols as a resource to pathologists to aid in effectively reporting surgical pathology findings necessary to provide quality patient care. The protocols consist of cancer case summaries accompanied by background documentation. The background documentation includes detailed outlines, explanatory notes, and references.

The Cancer Biomarker Reporting Templates are produced to establish reporting guidance for commonly ordered biomarkers, create stand-alone reporting templates, and improve consistency and completeness of results reporting to assist tumor registrars and others involved in data collection, exchange, and surveillance. These reporting templates are intended to encompass all important data elements for routinely assessed tumor markers and are designed to be incorporated into electronic reporting systems. Completion of the template is the responsibility of the laboratory performing the biomarker testing and/or providing the interpretation.

Use of the Cancer Biomarker Reporting Templates is entirely optional and is currently not a requirement for laboratory accreditation.

Additional information on the CAP Cancer Biomarker Reporting Templates

Review a summary of all the 2013-2014 revisions (PDF, 742 KB) to the CAP Cancer Protocols. A summary of changes is in the Protocol Revision History section on page three of each individual protocol.

We look forward to answering any questions you may have regarding the CAP Cancer Protocols. Please direct your comments to CProtocol@cap.org.

Copyright, Disclaimer and Authorized Use Licensing Model. What is a Work Aid?

Important Notes

Pathologists can and should begin using the updated protocols as soon as possible after web posting. Vendors should undertake implementation of the new checklists into their products as soon as possible.

The CAP recognizes that full implementation by some institutions and laboratory informatics software vendors may require a period of months. The CAP plans to recognize an 8 month period of overlap for LAP accredited laboratories in which either the previous or new version of the protocol may be used.



Copyright and Disclaimer

The checklists are protected by copyright and cannot be used in an information system without a license. Please read the copyright, disclaimer and authorized use licensing model for terms and conditions.




Protocols Download
Breast
DCIS – Breast Updated
Posted: December 18, 2013
PDF
(601 KB)
Word
(461 KB)
2012 Version
(PDF, 357 KB)
Invasive Breast Updated
Posted: December 18, 2013
PDF
(2 MB)
Word
(1 MB)
2012 Version
(PDF, 1.2 MB)
Work Aid
(Word, 137 KB)
  • Breast Biomarker Reporting Updated
    Posted: December 2, 2014
PDF
(239 KB)
Word
(173 KB)
2013 Version
(422 KB)
 
Central Nervous System
Brain/Spinal Cord Updated
Posted: December 2, 2014
PDF
(268 KB)
Word
(202 KB)
2013 Version
(217 KB)
  • CNS Biomarker Reporting New
    Posted: December 2, 2014
PDF
(992 KB)
Word
(196 KB)
   
Endocrine
Adrenal Gland Updated
Posted: October 1, 2013
PDF
(858 KB)
Word
(647 KB)
2012 Version
(PDF, 815 KB)
Appendix NET Updated
Posted: October 1, 2013
PDF
(372 KB)
Word
(262 KB)
2012 Version
(PDF, 513 KB)
Colon NET Updated
Posted: October 1, 2013
PDF
(382 KB)
Word
(266 KB)
2012 Version
(PDF, 512 KB)
Pancreas (Endocrine) Updated
Posted: October 1, 2013
PDF
(2 MB)
Word
(1.9 MB)
2012 Version
(PDF, 1.4 MB)
Small Intestine NET Updated
Posted: October 1, 2013
PDF
(395 KB)
Word
(270 KB)
2012 Version
(PDF, 522 KB)
Stomach NET Updated
Posted: October 1, 2013
PDF
(175 KB)
Word
(71 KB)
2012 Version
(PDF, 81 KB)
Thyroid
Posted: August 12, 2014
PDF
(545 KB)
Word
(743 KB)
2012 Version
(PDF, 2.4 KB)
Gastrointestinal
Ampulla of Vater Updated
Posted: October 1, 2013
PDF
(739 KB)
Word
(974 KB)
2012 Version
(PDF, 722 KB)
Anus Updated
Posted: October 1, 2013
PDF
(778 KB)
Word
(1.1 MB)
2012 Version
(PDF, 766 KB)
Appendix Updated
Posted: October 1, 2013
PDF
(173 KB)
Word
(77 KB)
2012 Version
(PDF, 170 KB)
Colon and Rectum Updated
Posted: October 1, 2013
PDF
(2.5 MB)
Word
(2.2 MB)
2012 Version
(PDF, 1.8 MB)
Work Aid
(Word, 125 KB)
  • Colon and Rectum
    Biomarker Reporting
    Updated
    Posted: December 2, 2014
PDF
(1.9 MB)
Word
(105 KB)
2013 Version
(1.6 MB)
Distal Extrahepatic Bile Ducts Updated
Posted: October 1, 2013
PDF
(457 KB)
Word
(338 KB)
2012 Version
(PDF, 250 KB)
Esophagus Updated
Posted: October 1, 2013
PDF
(4.5 MB)
Word
4.1 MB)
2012 Version
(PDF, 7 MB)
Work Aid
(Word, 122 KB)
Gallbladder Updated
Posted: October 1, 2013
PDF
(967 KB)
Word
(853 MB)
2012 Version
(PDF, 749 KB)
GIST Updated
Posted: December 2, 2014
PDF
(1.3 MB)
Word
(274 KB)
2013 Version
(1.6 MB)
  • GIST Biomarker Reporting New
    Posted: December 2, 2014
PDF
(810 KB)
Word
(1.5 MB)
   
Hepatocellular Carcinoma
Posted: June 15, 2012
PDF
(654 KB)
Word
(509 KB)
2011 Version
(PDF, 652 KB)
Intrahepatic Bile Ducts Updated
Posted: October 1, 2013
PDF
664 KB)
Word
(509 KB)
2012 Version
(PDF, 834 KB)
Pancreas (Exocrine) Updated
Posted: October 1, 2013
PDF
(1.5 MB)
Word
(1.9 MB)
2012 Version
(PDF, 1.4 MB)
Perihilar Bile Ducts Updated
Posted: October 1, 2013
PDF
(468 KB)
Word
(345 KB)
2012 Version
(PDF, 448 KB)
Small Intestine Updated
Posted: October 1, 2013
PDF
(1.3 MB)
Word
(1.2 MB)
2012 Version
(PDF, 1 MB)
Stomach Updated
Posted: June 11, 2013
PDF
1.4 KB)
Word
(2.3 MB)
2013 Version
(PDF, 718 KB)
  • Gastric HER2 Biomarker Reporting
    Posted: June 11, 2014
PDF
(0.97 MB)
Word
(57.5 kB)
Genitourinary
Kidney Updated
Posted: October 1, 2013
PDF
(1.5 MB)
Word
(408 KB)
2012 Version
(PDF, 1.4 MB)
Work Aid
(Word, 123 KB)
Penis Updated
Posted: October 1, 2013
PDF
(5.1 MB)
Word
(4.1 MB)
2011 Version
(PDF, 227 KB)
Prostate Gland
Posted: June 15, 2012
PDF
(542 KB)
Word
(284 KB)
2011 Version
(PDF, 542 KB)
Work Aid
(Word, 112 KB)
Testis Updated
Posted: October 1, 2013
PDF
(760 KB)
Word
(693 KB)
2012 Version
(PDF, 729 KB)
Ureter, Renal
Pelvis
Updated
Posted: October 1, 2013
PDF
(722 KB)
Word
(306 KB)
2012 Version
(PDF, 708 KB)
Urethra Updated
Posted: October 1, 2013
PDF
(183 KB)
Word
(100 KB)
2012 Version
(PDF, 179 KB)
Urinary Bladder Updated
Posted: October 1, 2013
PDF
(215 KB)
Word
(115 KB)
2012 Version
(PDF, 216 KB)
Gynecologic
Endometrium Updated
Posted: December 18, 2013
PDF
(688 KB)
Word
(323 KB)
2012 Version
(PDF, 679 KB)
Work Aid
(Word, 126 KB)
Fallopian Tube Updated
Posted: October 1, 2013
PDF
(1.8 MB)
Word
(856 KB)
2012 Version
(PDF, 1.7 MB)
Ovary Updated
Posted: October 1, 2013
PDF
(1.9 MB)
Word
(878 KB)
2012 Version
(PDF, 1.8 MB)
Trophoblastic Tumors Updated
Posted: October 1, 2013
PDF
(188 KB)
Word
(65 KB)
2012 Version
(PDF, 181 KB)
Uterine Cervix Updated
Posted: December 18, 2013
PDF
(209 KB)
Word
(127 KB)
2012 Version
(PDF, 202 KB)
Uterine Sarcoma New
Posted: December 18, 2013
PDF
(213 KB)
Word
(246 KB)
 
Vagina Updated
Posted: December 18, 2013
PDF
(161 KB)
Word
(83 KB)
2011 Version
(PDF, 152 KB)
Vulva
Posted: June 15, 2012
PDF
(172 KB)
Word
(98 KB)
2011 Version
(PDF, 77 KB)
Head and Neck
Larynx Updated
Posted: October 1, 2013
PDF
(1.1 MB)
Word
(1.2 MB)
2012 Version
(PDF, 1.2 MB)
Lip and Oral Cavity Updated
Posted: October 1, 2013
PDF
(2.5 MB)
Word
(1.7 MB)
2012 Version
(PDF, 2.3 MB)
Major Salivary Glands Updated
Posted: October 1, 2013
PDF
(818 KB)
Word
(610 KB)
2012 Version
(PDF, 771 KB)
Nasal Cavity and Paranasal Sinuses Updated
Posted: October 1, 2013
PDF
(528 KB)
Word
(511 KB)
2012 Version
(PDF, 488 KB)
Pharynx Updated
Posted: October 1, 2013
PDF
(2.1 MB)
Word
(2.2 MB)
2012 Version
(PDF, 2 MB)
Hematologic
Bone Marrow
Posted: June 15, 2012
PDF
(185 KB)
Word
(92 KB)
2011 Version
(PDF, 129 KB)
  • Chronic Lymphocytic Leukemia Biomarker Reporting New
    Posted: December 2, 2014
PDF
(1.2 MB)
Word
(73 KB)
 
  • Chronic Myelogenous Leukemia Biomarker Reporting New
    Posted: December 2, 2014
PDF
(1.2 MB)
Word
(82 KB)
 
  • Diffuse Large B-Cell Lymphoma Biomarker Reporting New
    Posted: December 2, 2014
PDF
(1.3 MB)
Word
(87 KB)
 
  • Myeloproliferative Neoplasms Biomarker Reporting New
    Posted: December 2, 2014
PDF
(1.1 MB)
Word
(81 KB)
 
Hodgkin Lymphoma Updated
Posted: October 1, 2013
PDF
(165 KB)
Word
(90 KB)
2012 Version
(PDF, 165 KB)
Non-Hodgkin Lymphoma Updated
Posted: October 1, 2013
PDF
(264 KB)
Word
(132 KB)
2010 Version
(PDF, 264 KB)
Work Aid
(Word, 102 KB)
Ocular Adnexal Lymphoma
Posted: June 15, 2012
PDF
(181 KB)
Word
(94 KB)
2010 Version
(PDF, 134 KB)
Ophthalmic
Retinoblastoma Updated
Posted: October 1, 2013
PDF
(475 KB)
Word
(259 KB)
2012 Version
(PDF, 475 KB)
Uveal Melanoma Updated
Posted: October 1, 2013
PDF
(508 KB)
Word
(283 KB)
2012 Version
(PDF, 508 KB)
Pediatric
Extragonadal Germ Cell
Posted June 15, 2012
PDF
(278 KB)
Word
(217 KB)
2011 Version
(134 KB)
Hepatoblastoma Updated
Posted: October 1, 2013
PDF
(212 KB)
Word
(82 KB)
2012 Version
(PDF, 212 KB)
Neuroblastoma
Posted: June 15, 2012
PDF
(238 KB)
Word
(165 KB)
2012 Version
(PDF, 238 KB)
PNET/Ewing Sarcoma
Posted: June 15, 2012
PDF
(401 KB)
Word
(519 KB)
2011 Version
(PDF, 410 KB)
Rhabdomyosarcoma
Posted: June 15, 2012
PDF
(203 KB)
Word
(104 KB)
2011 Version
(PDF, 203 KB)
Wilms Tumor
Posted: June 15, 2012
PDF
(182 KB)
Word
(97 KB)
2011 Version
(PDF, 98 KB)
Skin
Melanoma Updated
Posted: October 1, 2013
PDF
(653 KB)
Word
(707 KB)
2012 Version
(622 KB)
Work Aid
(Word, 115 KB)
Merkel Cell Carcinoma
Posted: June 15, 2012
PDF
(545 KB)
Word
(543 KB)
2011 Version
(107 KB)
Squamous Cell Carcinoma Updated
Posted: October 1, 2013
PDF
(168 KB)
Word
(84 KB)
2012 Version
(159 KB)
Thorax
Heart
Posted: June 15, 2012
PDF
(114 KB)
Word
(59 KB)
2012 Version
(PDF, 114 KB)
Lung Updated
Posted: October 1, 2013
PDF
(1.4 MB)
Word
(363 KB)
2012 Version
(1.3 MB)
Work Aid
(Word, 137 KB)
  • Lung Biomarker
    Reporting

    Posted: October 1, 2013
PDF
(1.3 MB)
Word
(66 KB)
Pleural Mesothelioma
Posted: June 15, 2012
PDF
(135 KB)
Word
(78 KB)
2011 Version
(44 KB)
Thymoma and Thymic Carcinoma
Posted: June 15, 2012
PDF
(133 KB)
Word
(72 KB)
2011 Version
(PDF, 133 KB)
Other
Bone Updated
Posted: October 1, 2013
PDF
(289 KB)
Word
(238 KB)
2012 Version
(266 KB)
Peritoneum Updated
Posted: October 1, 2013
PDF
(115 KB)
Word
(63 KB)
2011 Version
(PDF, 113 KB)
Soft Tissue Updated
Posted: October 1, 2013
PDF
(243 KB)
Word
(183 KB)
2012 version
(233 KB)