College of American Pathologists


  This page and related links last reviewed on October 17, 2012


Resources Resources

Analyte Specific Reagents

ASRs are reagents composed of chemicals or antibodies that may be thought of as the “active ingredients” of in-house developed tests and purchased from manufacturers under this label. Learn more

Abstracts Articles

Goldstein NS, Hewitt SM, Taylor CR, et al. Recommendations for improved standardization of immunohistochemistry. Appl Immunohistochem Mol Morphol. 2007;15:124-133.

Dorfman DM, Bui MM, Tubbs RR, et al. The CD117 immunohistochemistry tissue microarray survey for quality assurance and inter-laboratory comparison. Arch Pathol Lab Med. 2006;130:779-782.

Fitzgibbons PL, Murphy DA, Dorfman DM, et al. Interlaboratory comparison of immunohistochemical testing for HER2: Results of the College of American Pathologists HER2 Immunohistochemistry Tissue Microarray Program. Arch Pathol Lab Med. 2006; 130:1440-1445.

Wolff AC, Hammond ME, Schwartz JN, et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. Arch Pathol Lab Med. 2007;131:18-43 (also J Clin Oncol 2007;25:1-28.)

Bogen S, Vani K, Sompuram S, Fitzgibbons PL. National HER2 proficiency test results using standardized quantitative controls: I. Characterization of laboratory failures. Arch Pathol Lab Med. (in press)

Cell Markers and Cytogenetics Committees College of American Pathologists. Clinical Laboratory Assays for Her2/neu Amplification and Overexpression; Quality Assurance, Standardization, and Proficiency Testing. Arch Pathol Lab Med. 2002;126:803-808.

Tubbs RR, Nagle R, Kelsie K, Pettigrew NM, Said JW, Corwin DJ, Rickert RR, Roche PC. Extension of useful reagent shelf life beyond manufacturers’ recommendations. Cell Markers Committee of the College of American Pathologists. Arch Pathol Lab Med. 1998;122:1051-1052.

Wold LE, Corwin DJ, Rickert RR, Pettigrew N, Tubbs RR. Interlaboratory variability of immunohistochemical stains. Results of the Cell Markers Survey of the College of American Pathologists. Arch Pathol Lab Med. 1989;113:680-683.

Immunohistochemistry Links Immunohistochemistry

Immunohistochemistry vade mecum


IHC World (Online Information Center for Immunohistochemistry)


Society for Applied Immunohistochemistry



Books and Articles Books

Quality Management in Anatomic Pathology: Promoting Patient Safety Through Systems Improvement and Error Reduction (2005)

Quality Management In Clinical Laboratories: Promoting Patient Safety Through Risk Reduction And Continuous Improvement (2005)

Best Practices in Diagnostic Immunochemistry Best Practices in Diagnostic Immunochemistry

Turner, Matthew S., Goldsmith, Jeffrey D. Best Practices in Diagnostic Immunohistochemistry: Spindle Cell Neoplasms of the GI Tracts. Arch Pathol Lab Med. 2009;133:1370-1374.

Garcia, Christine F., Swerdlow, Steven H. Best Practices in Diagnostic Immunohistochemistry: Panel Approach to Hematolymphoid Proliferations Arch Pathol Lab Med. 2009;133:756-765.

Paner, Gladell P., Luthringer, Daniel J., Amin, Mahul B. Best Practices in Diagnostic Immunohistochemistry: Prostate Carcinoma and its Mimics in Needle Core Biopsies Arch Pathol Lab Med. 2008;132:1388-1396.

Folpe AL, Cooper K. Best Practices in Diagnostic Immunohistochemistry: Pleomorphic Cutaneous Spindle Cell Tumors. Arch Pathol Lab Med. 2007;131:1517-1524.

Kakar S, Gown AM, Goodman ZD, Ferrell LD. Best Practices in Diagnostic Immunohistochemistry: Hepatocellular Carcinoma Versus Metastatic Neoplasms. Arch Pathol Lab Med. 2007;131:1648-1654.

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