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Note that recommendations in the 2007 ASCO/CAP Guideline for HER2 Testing have been reconciled with the April 2010 ASCO/CAP ER PgR Guideline so that cancer specimens will be handled in a uniform manner for ER, PgR and HER2 in breast cancer specimens.
Read the Clinical Notice (PDF, 65 K)
See Easy Reference Reconciliation Table (PDF, 29 K)
A joint letter to the editor in the Journal of Clinical Oncology provides an important reminder of the intent of the ASCO and College of American Pathologists (CAP) guideline panel on Human Epidermal Growth Factor Receptor 2 (HER2) Testing, and also reconciles some pathology technical aspects with the recent guideline on Immunohistochemical Testing of Estrogen and Progesterone Receptor (ER and PgR) Testing in breast cancer. Read the letter by Elizabeth Hammond, MD, Daniel F. Hayes, MD and Antonio Wolff, MD, co-chairs of the ASCO/CAP guideline panels.
Summary of ER/PgR Recommendations – Revised
(PDF, 235 K)
See Frequently Asked Questions for information on specimen handling for HER2 and ER/PgR testing.
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The College of American Pathologists (CAP) and the American Society of Clinical Oncology (ASCO) joint guideline on testing for ER/PgR in breast cancer.
CAP and ASCO Press Release
Comment on the guidelines
This list is offered as a service to laboratories seeking a reference laboratory that offers ER/PgR assay validation services.
Frequently asked questions about the ER/PgR guideline.
Information for patients
Breast Predictive Factors Testing Advanced Practical Pathology Program
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CAP Accreditation Program requirements for ER/PgR testing are being created and will be available in the June 2010 edition of the Anatomic Pathology (ANP) Accreditation Checklist. These new requirements will assure the quality of ER/PgR testing provided by accredited laboratories and incorporate CAP/ASCO ER/PgR guideline recommendations into the CAP accreditation program.
CAP accredited laboratories performing ER/PgR testing will be required to enroll and participate in CAP-accepted proficiency testing by 2011.
Learn more about new and revised checklist requirements.
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With CAP Surveys, you can prepare to meet the PT requirements as outlined in the newly adopted CAP/ASCO ER/PgR guideline and the upcoming CAP accreditation checklist requirements.
To order the appropriate program(s) for your laboratory, please call the CAP Customer Contact Center at 1-800-323-4040 option 1.
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ER/PgR Guideline
