In Vivo Microscopy
Topic Center


In vivo microscopy (IVM) is a new field where microscopic images are obtained in real time. These technologies currently use light and can rapidly produce images in 2D or 3D. Images may be obtained using instrumentation that can be inserted into endoscope accessory ports or as standalone imaging tools.

Goals of IVM

  • Guide the acquisition of targeted and more meaningful biopsies
  • Screen entire organs for occult microscopic disease
  • Obtain microscopic diagnoses when tissues cannot be easily or safely excised
  • Assess the efficacy of therapy

IVM Resource Guide

The In vivo Microscopy Resource Guide contains a set comprehensive resources providing understanding of IVM/EVM technology and applications, plus insights from early adopters. The digital publication is free to College of American Pathologists' (CAP) members. A printed edition may be purchased by both members and nonmembers.

IVM-Related Resources

IVM Short Presentations on Emerging Concepts (SPECs) – Downloadable educational PowerPoint presentations on IVM for members

The CAP IVM committee has created ten-minute educational briefs to provide better understanding about emerging applications of IVM/EVM technology.

The CAP IVM committee created a new subsection of the Anatomic Pathology Checklist which promotes best practices in In Vivo Microscopy.

IVM Webinars

The CAP IVM webinar series provides education about various applications of IVM/EVM. View the webinars section to find more details about these events and to access previous webinars.

April 25, 2017

11:00 am CDT

Confocal Microscopy for Pigmented Lesions

Speaker: Babar Rao, MD

May 30, 2017

11:00 am CDT

Creating a Successful Pathology-engineering Collaboration

Speaker: Nicholas P. Reder, MD, MPH

July 18, 2017

12:00 pm CDT

GI for Inflammatory Intestine

Speaker: Gary Tearney, MD, PhD, FCAP

Oct 3, 2017

11:00 am CDT

Light-sheet Microscopy for 3D Pathology

Speaker: Nicholas P. Reder, MD, MPH

Nov 7, 2017

11:00 am CDT

Rapid Examination of Fresh Tissue Using Light-sheet Microscopy

Speaker: Nicholas P. Reder, MD, MPH

Get Involved With CAP IVM Projects

Email CAP to get involved with CAP IVM projects or to request to be on the CAP IVM mailing list. Apply for the IVM Committee.

*Image courtesy of DongKyun Kang, the Tearney Lab and Massachusetts General Hospital.

- Login and CAP Membership Required.


Free IVM Interpretation Course

Space is limited for our September 2017 IVM program in Chicago.