Initial Diagnostic Workup of Acute Leukemia



The College of American Pathologists' (CAP) Pathology and Laboratory Quality Center and the American Society of Hematology (ASH) collaborated to develop a clinical practice guideline for the diagnostic workup of acute leukemia.

This evidence-based guideline, "Initial Diagnostic Workup of Acute Leukemia: Guideline from the CAP and ASH," is available as an early online release in the Archives of Pathology & Laboratory Medicine.

The CAP and ASH formed an interdisciplinary expert panel of hematologists and hematopathologists to systematically review published evidence to answer six questions for the initial diagnosis of acute leukemia, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), mixed-phenotype acute leukemia (MPAL), and acute leukemias of ambiguous lineage:

  1. What clinical and laboratory information should be available?
  2. What samples and specimen types should be evaluated?
  3. What tests are required for all patients during the initial evaluation?
  4. What tests are required for only a subset of patients?
  5. Where should laboratory testing be performed?
  6. How should the results be reported?

Guideline Resources

Download the following tools and resources to help implement the guideline:

Clinical teams should adopt the new guideline to improve diagnosis, treatment, and outcomes for acute leukemia patients.

Patient and Caregiver Resources

The CAP, ASH, and the Leukemia & Lymphoma Society created tools and resources to support patients with acute leukemia during their diagnosis and treatment. Download the following to learn more:


Question or Comment?


Guideline status: Active

Published online ahead of print: February 22, 2017

Originally published: October 2017