Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Tyrosine Kinase Inhibitors



The College of American Pathologists (CAP), the International Association for the Study of Lung Cancer (IASLC), and the Association for Molecular Pathology (AMP) have followed up their 2013 evidence-based guideline with the Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors." The new guideline continues to set evidence-based standards for clinical molecular testing of non-small cell lung cancers (NSCLC) that effectively guides targeted therapy and treatment.

Rapid advancements in the understanding of lung cancer, and corresponding growth in available molecularly-targeted therapies, make this guideline revision essential to guide optimal patient care. NSCLC patients whose tumors harbor specific molecular alterations may be candidates for targeted tyrosine kinase inhibitor therapy, which may improve survival and quality of life.

The updated guideline strengthens or reaffirms the majority of 2013 recommendations for patients with lung adenocarcinoma, and it also recommends testing for some new genes. Most notably, the guideline provides answers to these important clinical questions:

  • Which new genes should be tested for lung cancer patients?
  • What methods should be used to perform molecular testing?
  • Is molecular testing appropriate for lung cancers that do not have an adenocarcinoma component?
  • What testing is indicated for patients with targetable mutations who have relapsed on targeted therapy?
  • What is the role of testing for circulating cell-free DNA for lung cancer patients?

Patients battling lung cancer will benefit as their clinicians review and adopt this guideline. Stakeholders around the world are encouraged to review the guideline and implement recommendations.

Guideline Resources

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