Serving as the expert scientific and educational resource for the College of American Pathologists (CAP).
Educational resources on diagnostic immunology and flow cytometry
Immunology-Related Journal Articles
- Laboratory Detection and Initial Diagnosis of Monoclonal Gammopathies: Guidelines From the College of American Pathologists in Collaboration With the American Association for Clinical Chemistry and the American Society for Clinical Pathology
- Variability in the Laboratory Measurement of Cytokines: A Longitudinal Summary of a College of American Pathologists Testing Survey
- Criteria for Diagnosis, Staging, Risk Stratification and Response Assessment of Multiple Myeloma
- Screening and Diagnosis of Monoclonal Gammopathies. An International Survey of Laboratory Practice
- New Insights on the Analytical Performances for Detecting and Quantifying Monoclonal Proteins (Editorial)
- An International Multi-Center Serum Protein Electrophoresis Accuracy and M-Protein Isotyping Study. Part I: Factors Impacting Limit of Quantitation of Serum Protein Electrophoresis.
- An International Multi-Center Serum Protein Electrophoresis Accuracy and M-Protein Isotyping Study. Part II: Limit of Detection and Follow-up of Patients with Small M-Proteins.
Flow Cytometry-Related Journal Articles
- CAP Flow Cytometry Checklist; Difficult and New Items (International Clinical Cytometry Society (ICCS) e-Newsletter, 2015:6(2)) (PDF, 1.4 MB)
- Marked Variability in Reported Minimal Residual Disease Lower Level of Detection of 4 Hematolymphoid Neoplasms
- EuroFlow Standardization of Flow Cytometer Instrument Settings and Immunophenotyping Protocols
- EuroFlow Antibody Panels for Standardized N-dimensional Flow Cytometric Immunophenotyping of Normal, Reactive and Malignant Leukocytes
- Standardization of flow cytometry in myelodysplastic syndromes: a report from an international consortium and the European LeukemiaNet Working Group (PDF, 655, KB)
- Diagnosing PNH with FLAER and multiparameter flow cytometry (PDF, 1.4 KB)
- Practice parameter for the diagnosis and management of primary immunodeficiency (PDF, 458 KB)
- Establishment and Validation of a Standard Protocol for the Detection of Minimal Residual Disease in B Lineage Childhood Acute Lymphoblastic Leukemia by Flow Cytometry in a Multi-Center Setting (PDF, 171 KB)
- Minimal Residual Disease Quantitation in Acute Myeloid Leukemia (PDF, 175 KB)
- Report of the European Myeloma Network on Multiparametric Flow Cytometry in Multiple Myeloma and Related Disorders (PDF, 192 KB)
Guidelines, Consensus Statements, and Recommendations
- International Myeloma Working Group Guidelines for Serum-Free Light Chain Analysis in Multiple Myeloma and Related Disorders (PDF, 347 KB)
- NCCN guidelines on multiple myeloma (PDF, 301 KB)
- 2006 Bethesda International Consensus Recommendations
- Flow Cytometric Immunophenotypic Analysis of Hematolymphoid Neoplasia: Medical Indications (The Cytometry Part B: Clinical Cytometry Supplement 72B:S5-S13, 2007)
- Immunophenotypic Analysis of Hematolymphoid Neoplasia by Flow Cytometry: Optimal Reagents and Reporting for the Flow Cytometric Diagnosis of Hematopoietic Neoplasia (The Cytometry Part B: Clinical Cytometry Supplement 72B:S14-S22, 2007)
- Immunophenotypic Analysis of Hematolymphoid Neoplasia by Flow Cytometry: Recommendations for Training and Education to Perform Clinical Flow Cytometry (The Cytometry Part B: Clinical Cytometry Supplement 72B:S23-S33, 2007)
- The International Consensus Statement on an update of the Classification Criteria for Definite Antiphospholipid Syndrome [(APS) Miyakis S, Lockshin MD, Atsumi T, et al. JThromb Haemost. 2006;4:295-306)
- Consensus Guidelines on Anti-Beta 2 Glycoprotein I Testing and Reporting (Wong RCW, Favaloro EJ, Adelstein S, et al. Pathology. 2008;40:58-63)
- Update of the Guidelines for Lupus Anticoagulant Detection (Pengo V, Tripodi A, Reber G, et al. J Thromb Haemost. 2009;7:1737-1740)
Clinical and Laboratory Standards Institute Documents
- Clinical Flow Cytometric Analysis of Neoplastic Hematolymphoid Cells; Approved Guideline – Second Edition (Clinical and Laboratory Standards Institute, document H43-A2)
- Enumeration of Immunologically Defined Cell Populations by Flow Cytometry; Approved Guideline – Second Edition (Clinical and Laboratory Standards Institute, document H42-A2)
- Evaluation Methods and Analytical Performance Characteristics of Immunological Assays for Human Immunoglobulin E (IgE) Antibodies of Defined Allergen Specificities; Approved Guideline (Clinical and Laboratory Standards Institute, document I/LA20-A)
- Quality Assurance of Laboratory Tests for Autoantibodies to Nuclear Antigens: (1) Indirect Fluorescence Assay for Microscopy and (2) Microtiter Enzyme Immunoassay Methods (Clinical and Laboratory Standards Institute, document ILA02-A2)
Join the Diagnostic Immunology and Flow Cytometry Committee
Learn more about our committee activities and how to join the Diagnostic Immunology and Flow Cytometry Committee.