An interdisciplinary expert panel of hematologists and hematopathologists to systematically review published evidence to answer six questions for the initial diagnosis of acute leukemia, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), mixed-phenotype acute leukemia (MPAL), and acute leukemias of ambiguous lineage:
- What clinical and laboratory information should be available?
- What samples and specimen types should be evaluated?
- What tests are required for all patients during the initial evaluation?
- What tests are required for only a subset of patients?
- Where should laboratory testing be performed?
- How should the results be reported?
The College of American Pathologists' (CAP) Pathology and Laboratory Quality Center and the American Society of Hematology (ASH) collaborated to develop the clinical practice evidence-based guideline, "Initial Diagnostic Workup of Acute Leukemia: Guideline from the CAP and ASH," is available in the Archives of Pathology & Laboratory Medicine.
- Guideline status: Active
- Published online ahead of print: February 22, 2017
- Originally published: October 2017
Guideline Tools and Resources
Download the following tools and resources to help implement the guideline:
- Summary of Recommendations (PDF, 128 KB)
- Methodology Supplement (Supplemental Digital Content) (PDF, 689 KB)
- Teaching Presentation (PDF, 341 KB)
- Frequently Asked Questions (PDF, 117 KB)
- Infographic (PDF, 548 KB)
Clinical teams should adopt the new guideline to improve diagnosis, treatment, and outcomes for acute leukemia patients.
This guideline was endorsed by the American Society of Clinical Oncology on December 3, 2018.