Current CAP Guidelines

The Center evidence-based guidelines help pathologists and other clinicians make more informed decisions about diagnosis and optimal treatment, and place emphasis on the pathologist's role to the center of patient care. Learn more about our guideline development.

1. Human Papillomavirus Testing in Head and Neck Carcinomas – 2025 Update
2. PDL-1 and TMB Testing in Lung Tumors
3. Principles of Analytic Validation of Immunohistochemical Assays – 2024 Update
4. HER2 Testing in Breast Cancer - 2023 Guideline Update
5. Mismatch Repair and Microsatellite Instability Testing for Immune Checkpoint Inhibitor Therapy
6. Diagnostic Testing for Diffuse Gliomas
7. Laboratory Detection and Initial Diagnosis of Monoclonal Gammopathies
8. Validating Whole Slide Imaging for Diagnostic Purposes in Pathology - Update
9. Laboratory Workup of Lymphoma in Adults
10. Collection and Handling of Thoracic Small Biopsy and Cytology Specimens for Ancillary Studies
11. Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer – Update
12. Quantitative Image Analysis of HER2 IHC for Breast Cancer
13. Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors – Update
14. Effective Communication of Urgent Diagnoses and Significant Unexpected Diagnoses in Surgical Pathology and Cytopathology - Reaffirmation
15. Initial Diagnostic Workup of Acute Leukemia
16. Molecular Biomarkers for the Evaluation of Colorectal Carcinoma
17. HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma
18. Bone Marrow Synoptic Reporting for Hematologic Neoplasms
19. Interpretive Diagnostic Error Reduction
20. Uniform Labeling of Blocks and Slides in Surgical Pathology
21. The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions

The following guidelines produced by other organizations have been evaluated by the Center Guideline Committee and officially endorsed by the CAP.

American Society of Clinical Oncology Molecular and Cellular Diagnostics in Localized Prostate Cancer
Date endorsed: August 14, 2020

• Read the editorial discussing the role of the pathologist in the molecular and cellular diagnosis of prostate cancer.