The CAP Pathology and Laboratory Quality Center and the American Society for Colposcopy and Cervical Pathology (ASCCP) have released a joint guideline - The LAST Project for HPV-associated Lesions: Background and Consensus Recommendations.
The LAST Project's consensus recommendations provide a standardized diagnostic histopathologic terminology for squamous lesions associated with human papillomavirus (HPV) across lower anogenital tract body sites, including recommendations for the appropriate use of biomarkers to identify and distinguish these lesions.
Implementation of the new consensus recommendations will result in more reliable and reproducible diagnoses based on our current knowledge of the biology of HPV-ultimately leading to more effective patient management and improved patient outcomes.
Physicians will receive more consistent biopsy diagnoses to help assess management options, including conservative follow-up or treatment, and more accurately evaluate a patient's risk of having precancer.
The LAST consensus recommendations are based on an extensive literature review of terminology used historically, how terminology influences management of HPV-associated lesions by body sites, and the role of biomarkers in diagnosis. Thirty-five professional organizations participated in the deliberations, revisions, and final approval of the LAST consensus recommendations.
- Guideline status: In review
- Published online ahead of print: June 28, 2012
- Originally published: October 2012
Download the following:
- Summary Recommendations
- LAST Biomarkers for HPV-Associated Lesions Algorithm Chart (PDF, 307 KB)
- LAST PowerPoint Presentation (PDF, 9 MB)
- ASCCP Educate the Educators Newsletter (PDF, 269 KB)
- Case Examples Illustrating Biomarker Usage Webinar and Q & A (PDF, 41 KB)
- Frequently Asked Questions: LAST (PDF, 78 KB)
- Methodology Supplement (PDF, 715 KB)