Frequently Asked Questions, Sample Exchange Registry

How does the Sample Exchange Registry program work?

To ensure a quality experience using this service, the CAP requires a minimum of three participants testing for the same analyte and methodology prior to facilitating the exchange process. Once your information through the Contact Information Form has been received, it will be placed in the system awaiting additional participants. The CAP will contact you once the above criteria have been met.

How does the IHC Validation Program work?

Since it is often difficult to assemble positive cases for markers of rare conditions, the CAP is facilitating a collaborative effort among laboratories to "crowd source" the necessary case material. As soon as there are ten laboratories willing to exchange tissue cases for the same marker, a validation study will begin.

Do you have to be a CAP accredited laboratory to participate in these programs?

No, everyone is welcome to participate.

Is it possible to see a list of analytes submitted for the Sample Exchange and IHC Validation programs?

A list of submitted analytes is not available at this time.

Does our laboratory have to provide samples in order to participate? If not will the CAP provide the samples for exchange?

We do ask that each participating laboratory donate samples for assessment. However, it is not a requirement for admittance into the program. The CAP facilitates the exchange of specimens between laboratories and does not provide specimens.

For the IHC Validation Program, procuring numerous positive tissue cases from one institution is very difficult. We do ask that any laboratory participating in this program provide at least one positive case for each given marker.

What is the cost to participate in this program?

This service is complimentary. However, a nominal fee of $165 per unique sample will be charged for samples that are submitted that require viral marker testing. If this testing can be done at your facility, this fee is waived. Note that documentation MUST be provided. All samples, with the exception of purified DNA/RNA , formalin-fixed paraffin embedded (FFPE) tissue or urine specimens, require viral marker testing.

What kind of viral testing is needed?

All samples (excluding purified DNA/RNA , FFPE or urine) must be negative for hepatitis B surface antigen, hepatitis C antibody, and HIV I and II antibodies.

Is the exchange based solely on the analyte, regardless of the instrumentation or methodology? Does each lab determine its own criteria for acceptable performance?

The sample exchange is based on the ability to obtain at least three laboratories that have submitted results for the same analyte/method and/or instrument combination. Once this minimum criterion is achieved, the CAP will summarize the data and provide a report to each participating laboratory.

How many samples are sent and how often?

Samples are sent twice a year based on availability.

For the IHC Validation Program, since this program will be for validation studies, the frequency would depend on the demand.