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Pathology Case Challenge


Case of the Month is now called Pathology Case Challenge.

We heard your feedback—“Why is it called ‘Case of the Month’ when at least two cases go out each month?”—and have updated the program name. You’ll see the switch reflected in emails, on cap.org, and in the MyCAP app. And you can still expect to see the same great case content to keep your skills sharp and test your knowledge.

This program offers at least two challenging cases each month from the CAP Performance Improvement Program in Surgical Pathology. For each case, you will use a virtual microscope whole slide image of a surgical specimen to diagnose diseases.

You will be presented with information on each case including: specimen source, clinical history, laboratory findings, and a representative whole slide image of the surgical specimen. After you complete each case, you will receive a case summary with three multiple-choice questions that relate to the case.

Please note: DigitalScope® is supported with Microsoft Internet Explorer 11.0 (limited support for IE 9 and 10) or later, or FireFox 4.0 or later, or Safari 3 or the latest Google Chrome version.


A 62-year-old woman presents with a rapidly enlarging palpable breast mass. Mammography demonstrates a 5 cm irregular solid mass. The patient undergoes a needle biopsy followed by simple mastectomy. Immunohistochemical staining for AE1/AE3 and CK7 are negative in the tumor cells, but there is scattered positivity for CK5/6. Focally, the tumor cells show nuclear p63 and GATA3 positivity. There is no staining for estrogen receptor, progesterone receptor, or HER2 in the tumor cells. Scattered throughout, the tumor produces a cartilage-like matrix. In many slides, small round S100-positive glands composed of one layer of epithelium with central eosinophilic secretions are noted in close association with the tumor.

Read the Pathology Case Challenge

Previous Case Challenges

View a list of previous cases using the virtual microscope to examine various surgical specimens and diagnose diseases.

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