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Previous Pathology Case Challenges

  • Placenta

    A 30-year-old G1P0 woman with limited prenatal care presents with vaginal bleeding at 15 weeks’ gestation. There is no evidence of fetal development on ultrasound.

  • Inguinal Soft Tissue

    A 58-year-old man presents with ​a ​5-year history of a painless, slow-growing subcutaneous mass in the inguinal region

  • Lung

    A 69-year-old non-smoking Japanese woman ​presents ​with a history of multiple symptoms resembling​ ​transient ischemic attacks​. She​ undergoes a right lung middle lobectomy for a 6.5 cm subpleural, well​-​circumscribed mass.

  • Placenta

    A 30-year-old G1P1 woman from Arizona delivers a stillborn fetus at 27 weeks’ gestation. The untrimmed placenta weighs 233 grams and shows multiple infarcts.

  • Retroperitoneum

    A 22-year-old man with a history of colectomy presents with abdominal pain. Physical exam finds a palpable abdominal mass, which a CT scan confirms.

  • Uterus

    A 46-year-old woman presents with pelvic pain and abnormal vaginal bleeding. Endometrial biopsy shows proliferative endometrium.

  • Retroperitoneal Lymph Node

    A 45-year-old man presents with bilateral gynecomastia. On physical examination, a left testicular mass is identified.

  • Testicle

    A 62-year-old man presents with a painless testicular mass. A radical orchiectomy is performed, revealing a solid lobular tan mass measuring 4 cm.

  • Small Intestine

    A 67-year-old man presents with diarrhea, nausea, and intermittent fever. His medical history includes a thyroid carcinoma and a melanoma on his upper back, widely excised.

  • Abdominal Wall

    A 32-year-old woman undergoing antenatal care has an abdominal wall nodule measuring 2 cm early mid-trimester, which increases to 5 cm in the third trimester.

  • Adrenal Gland

    A 47-year-old woman with a history of sickle cell disease presents with increasing abdominal pain. A CBC demonstrates anemia and a CT scan reveals bilateral adrenal masses.

  • Neck, Soft Tissue

    A 19-year-old otherwise healthy man presents with a history of intermittent pain associated with an enlarging left neck mass.

  • Kidney

    A 3-year-old boy presents with a 12 cm solid heterogeneous mass within his right kidney.

  • Kidney

    A 62-year-old man presents with hematuria and flank pain. A computed tomography scan shows a 6 cm mass in the right kidney.

  • Heart

    A 60-year-old woman presents​ ​with shortness of breath and recent onset of weight loss. She expires shortly after admission.

  • Lung

    A 6-year-old girl with a history of persistent asthma is brought to urgent care with 5 days of cough and cold symptoms. She is in cardiopulmonary arrest.

  • Ovary

    A 53-year-old woman presents with abdominal pain and is found to have an ovarian mass.

  • Adult Granulosa Cell Tumor

    A 55-year-old woman presents with several weeks of postmenopausal bleeding and abdominal pain. A pelvis CT scan demonstrates a 13 cm right adnexal mass.

  • Hematology

    A 62-year-old engineer presented with fatigue, pallor, and weight loss for the past two months. Clinical examination revealed a palpable spleen and skin pallor.

  • Vulva

    A 39-year-old woman with no significant past medical history presents with a single 4-cm nodule located on the labia majora.

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