1. Home
  2. Protocols and Guidelines
  3. Current CAP Guidelines

Current CAP Guidelines

The Center evidence-based guidelines help pathologists and other clinicians make more informed decisions about diagnosis and optimal treatment, and place emphasis on the pathologist's role to the center of patient care. Learn more about our guideline development.

  1. Laboratory Workup of Amyloidosis
  2. Human Papillomavirus Testing in Head and Neck Carcinomas – 2025 Update
  3. PDL-1 and TMB Testing in Lung Tumors
  4. Principles of Analytic Validation of Immunohistochemical Assays – 2024 Update
  5. HER2 Testing in Breast Cancer - 2023 Guideline Update
  6. Mismatch Repair and Microsatellite Instability Testing for Immune Checkpoint Inhibitor Therapy
  7. Diagnostic Testing for Diffuse Gliomas
  8. Laboratory Detection and Initial Diagnosis of Monoclonal Gammopathies
  9. Validating Whole Slide Imaging for Diagnostic Purposes in Pathology - Update
  10. Laboratory Workup of Lymphoma in Adults
  11. Collection and Handling of Thoracic Small Biopsy and Cytology Specimens for Ancillary Studies
  12. Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer – Update
  13. Quantitative Image Analysis of HER2 IHC for Breast Cancer
  14. Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors – Update
  15. Effective Communication of Urgent Diagnoses and Significant Unexpected Diagnoses in Surgical Pathology and Cytopathology - Reaffirmation
  16. Initial Diagnostic Workup of Acute Leukemia
  17. Molecular Biomarkers for the Evaluation of Colorectal Carcinoma
  18. HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma
  19. Bone Marrow Synoptic Reporting for Hematologic Neoplasms
  20. Interpretive Diagnostic Error Reduction
  21. Uniform Labeling of Blocks and Slides in Surgical Pathology
  22. The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions

External Guidelines Endorsed by the CAP

The following guidelines produced by other organizations have been evaluated by the Center Guideline Committee and officially endorsed by the CAP.

American Society of Clinical Oncology Molecular and Cellular Diagnostics in Localized Prostate Cancer
Date endorsed: August 14, 2020

  • Read the editorial discussing the role of the pathologist in the molecular and cellular diagnosis of prostate cancer.

Learn More

Read how we develop evidence-based guidelines and view upcoming guidelines.

Learn about guideline development Right Arrow View upcoming guidelines Right Arrow
To Top