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Previous Cases of the Month

  • Penis

    Case of The Month uses a virtual microscope whole slide image (WSI) of a surgical specimen to diagnose diseases from the archives of the CAP PIP.

  • Thigh mass

    Case of the Month uses a virtual microscope whole slide image (WSI) of a surgical specimen to diagnose diseases from the archives of the CAP PIP.

  • Mediastinal mass

    Case of The Month uses a virtual microscope whole slide image (WSI) of a surgical specimen to diagnose diseases from the archives of the CAP PIP.

  • Liver

    Case of The Month uses a virtual microscope whole slide image (WSI) of a surgical specimen to diagnose diseases from the archives of the CAP PIP.

  • Ovary

    Case of the Month uses a virtual microscope whole slide image (WSI) of a surgical specimen to diagnose diseases from the archives of the CAP PIP.

  • Kidney

    Case of the Month uses a virtual microscope whole slide image (WSI) of a surgical specimen to diagnose diseases from the archives of the CAP PIP.

  • Left Arm

    Case of The Month uses a virtual microscope whole slide image (WSI) of a surgical specimen to diagnose diseases from the archives of the CAP PIP.

  • Kidney

    Case of The Month uses a virtual microscope whole slide image (WSI) of a surgical specimen to diagnose diseases from the archives of the CAP PIP.

  • Testis

    Case of The Month uses a virtual microscope whole slide image (WSI) of a surgical specimen to diagnose diseases from the archives of the CAP PIP.

  • Stomach

    Case of The Month uses a virtual microscope whole slide image (WSI) of a surgical specimen to diagnose diseases from the archives of the CAP PIP.

  • Transient Abnormal Myelopoiesis

    A 38-week-gestation boy was born to a 38-year-old mother. Pertinent physical exam findings included up-slanting eyes, webbed toes, and a murmur consistent with a ventricular septal defect. 

  • Third Trimester Placenta

    A 22-year-old G2P1 woman is admitted in labor via the emergency room (ER) to a local hospital. She informs the admitting physician that based on prior ultrasound evaluations her fetus exhibits findings consistent with intrauterine growth restriction and that she regularly visits the hospital’s obstetrical service, where she is being followed by a staff gynecologist. At the time of admission, she denies fever, cough, or skin rashes. Evaluation of her chart reveals that she is 37 weeks pregnant (by dates). Also noted are several pre-natal laboratory results, including the following: HBsAg-negative, RPR non-reactive, Rubella-immune, HIV non-reactive, GC-negative, and Chlamydia-negative. Due to fetal distress, she delivers via Cesarean-section later that day; the newborn male is small for gestational age. The placenta is submitted to the pathology department for evaluation.

  • Skin and soft tissue of right forearm

    A 45-year-old healthy construction worker sustains a superficial laceration to his arm at his worksite. He does not receive any immediate medical attention for the cut. Several weeks later he develops generalized erythema and discoloration of the skin of the upper extremity in the region of previous trauma. He finally requests medical attention due to pain and stiffness that prevents him from working. He requires an extensive surgical debridement of the skin and subcutaneous tissue for control of disease. At the time of surgery, material from the soft tissue wound is submitted for culture.

  • Soft tissue

    A 13-year-old boy presents with a soft tissue mass in the posterior aspect of the right knee. On palpation the mass is round and hard measuring 5.0 cm in diameter. Imaging studies include an ultrasound demonstrating a hyperechoic shell with a hypoechoic center. Gross examination shows a round mass with a calcific outer rim and an edematous fibrous appearing core.

  • Brain

    A 68-year-old woman presents with headache and seizures of recent onset. Computed tomography (CT) of the head shows a 4.0 x 3.0 cm contrast-enhancing, well-defined, left parasagittal mass compressing the parietal lobe. The mass is resected and on gross examination shows a firm, well-demarcated tan-white tumor attached to a small segment of dura.

  • Liver

    A 41-year-old woman presents with a one-month history of vague abdominal pain. Physical examination reveals mild right-upper quadrant tenderness. Computerized tomography (CT) imaging shows a solitary 12 cm cyst in the left lobe of the liver. No other imaging abnormalities are present in the chest, abdomen, or pelvis. Her serum alpha-fetoprotein, CEA, and CA19-9 are within normal limits.

  • Thymus

    A 71-year-old man expires in a nursing home and an autopsy is performed. At autopsy, he is found to have a strangulated segment of jejunum within an incisional hernia with resulting sepsis. In addition, an enlarged thymus weighing 30 grams is identified. Representative tissue is obtained from the enlarged thymus.

  • Lung

    A 77-year-old man presents with a 5.0 cm nodule on computerized tomography examination. The nodule is partly solid and partly ground glass, located in the periphery of the left lower lobe. The patient has a history of 2.0 cm poorly differentiated, non-small cell carcinoma in the right-upper lobe, which was resected 4 years prior. Gross examination of the left-lower lobectomy specimen reveals an ill-defined, solid mass puckering the overlying pleura. The cut section shows a tan-white, gelatinous, mucoid, lobulated mass measuring 5.0 cm in greatest dimension. Representative sections are submitted for microscopic sections.

  • Colon

    A 65-year-old man presents with intense abdominal pain and constipation. Computed tomography (CT)  scans reveal a single large abdominal mass involving the transverse colon as well as abdominal lymphadenopathy. After segmental resection of the transverse colon, a single mass is identified, with a fleshy, tan appearance on cut sections. Immunohistochemistry shows that the lesional cells express CD20, PAX5, CD10, BCL6, BCL2, and kappa light chain, but are negative for lambda light chain, CD5, BCL1, EBER, and cytokeratin AE1/3. The proliferative rate by Ki-67 is approximately 50%. No follicular dendritic meshworks are seen by CD21. Molecular testing is positive for t(14;18), but <em>MYC</em> gene rearrangements are not identified.

  • Liver

    A 24-year-old woman with no significant medical history presents with vague persistent abdominal discomfort. On computed tomography (CT) imaging a 5.3 cm, solitary, well-circumscribed liver lesion with a central area of scarring is identified within the left hepatic lobe. A resection of the lesion is performed.

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